Pain
The lipid sensor LXRs protect small sensory neurons... 29 September 2018
Our findings suggest that lipid-binding nuclear receptors expressed in the sensory neurons of the DRG play a role in the onset of obesity-induced hypersensitivity. The LXR and lipid-sensor pathways represent a research avenue to identify targets to prevent debilitating complications affecting the peripheral nerve system in obesity.
Read more >Obesity-Associated Neuropathy: Recent Preclinical Studies and Proposed Mechanisms 26 February 2022
In this review, we focus on interventions and their mechanisms that are shown to ameliorate neuropathy in MetS obese models including: (i) inhibition of a sensory neuron population, (ii), modification of dietary components, (iii) activation of nuclear and mitochondrial lipid pathways, (iv) exercise, (v) modulation of gut microbiome composition and their metabolites.
Read more >Fecal Transplantation and Butyrate Improve Neuropathic Pain, Modify... 15 October 2020
Circulating butyrate, a metabolite secreted by gut microbiome and absorbed in the blood stream, may be involved by acting directly on peripheral nerve system immune cells and gene expression or pain channels.
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