Microbiome
Obesity-Associated Neuropathy: Recent Preclinical Studies and Proposed Mechanisms 26 February 2022
In this review, we focus on interventions and their mechanisms that are shown to ameliorate neuropathy in MetS obese models including: (i) inhibition of a sensory neuron population, (ii), modification of dietary components, (iii) activation of nuclear and mitochondrial lipid pathways, (iv) exercise, (v) modulation of gut microbiome composition and their metabolites.
Read more >Fecal Transplantation and Butyrate Improve Neuropathic Pain, Modify... 15 October 2020
Circulating butyrate, a metabolite secreted by gut microbiome and absorbed in the blood stream, may be involved by acting directly on peripheral nerve system immune cells and gene expression or pain channels.
Read more >Vagal free fatty acid receptor (FFAR3), is necessary... 30 September 2021
Our data demonstrate that FFAR3 expressed in vagal neurons regulates feeding behavior and mediates propionate-induced decrease in food intake.
Read more >Communication between the gut microbiota and peripheral nervous... 1 May 2022
In this review, we cover the general anatomy and function of the PNS, and then we discuss how the molecules secreted or stimulated by gut microbes signal through the PNS to alter host development and physiology.
Fecal microbiome transplantation and tributyrin improves early cardiac... 2 March 2023
More than 50% of patients with heart failure present with heart failure with preserved ejection fraction (HFpEF), and 80% of them are overweight or obese. In this study we developed an obesity associated pre-HFpEF mouse model and showed an improvement in both systolic and diastolic early dysfunction following fecal microbiome transplant (FMT). Our study suggests that the gut microbiome-derived short-chain fatty acid butyrate plays a significant role in this improvement.
Read more >Short chain fatty acids: the messengers from down... 18 August 2023
Short-chain fatty acids (SCFAs), produced by the metabolism of dietary fibers in the gut, have wide-ranging effects locally and throughout the body. They modulate the enteric and central nervous systems, benefit anti-inflammatory pathways, and serve as energy sources. Recent research reveals SCFAs as crucial communicators between the gut and brain, forming the gut-brain axis. This perspective highlights key findings and discusses signaling mechanisms connecting SCFAs to the brain. By shedding light on this link, the perspective aims to inspire innovative research in this rapidly developing field.
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