Mansuy-Aubert Laboratory

Microbiota, Metabolism and Sensory Physiology

Since 2016 we elucidate how diet impacts nerves and metabolic health. Our goal is to develop therapies and nutrient guidelines to improve health, ageing, metabolic performance and prevent metabolic and neurological diseases. Our lab relocated from Chicago to Lausanne in the summer of 2022.

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Last publication - Aug 18 2023

Short chain fatty acids: the messengers...

Virginie Mansuy-Aubert and Yann Ravussin

Short-chain fatty acids (SCFAs), produced by the metabolism of dietary fibers in the gut, have wide-ranging effects locally and throughout the body. They modulate the enteric and central nervous systems, benefit anti-inflammatory pathways, and serve as energy sources. Recent research reveals SCFAs as crucial communicators between the gut and brain, forming the gut-brain axis. This perspective highlights key findings and discusses signaling mechanisms connecting SCFAs to the brain. By shedding light on this link, the perspective aims to inspire innovative research in this rapidly developing field.

Improve Neuronal Functions With Nutrition, the Gut Brain axis

Associate professor at the University of Lausanne, Virginie Mansuy Aubert research uses transgenic mouse models and advanced culture techniques to understand the mechanistic link between diet, microbiota and the autonomic functions. Her team is working on neurons and inflammatory cells that respond to changes in diet and in the microbiota derived metabolites, the short chain fatty acids. The microbiota / neuron/immune interaction generates changes in the brain and peripheral nerve systems that regulate appetite, heart function, energy expenditure and somatosensory function including pain.

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"Let food be thy medicine,
and let medicine be thy food."